This talk will describe how we can transform teaching and learning to prepare students with the skills they need for 21st-century work and citizenship. The array of Web 2.0 interactive media for students to create and share knowledge is rapidly expanding. In addition, immersive interfaces (e.g., virtual worlds, augmented realities) and mobile devices pervade the lives of students outside academic settings. We can build on these media to improve our teaching and assessment and to strengthen the links between life inside and outside the classroom. As discussed in the 2010 National Education Technology Plan, this can help our graduates succeed in the 21st century.